Great presentations at the rtx1 users e-symposium 2023! Replay available
02.10.2023
Two weeks ago, we had the pleasure to host the rtx1 users e-symposium 2023, chaired by Prof. Tunde Peto from Queen’s University Belfast, and Prof. Marie-Hélène Errera from University of Pittsburgh School of Medicine.
“There is so much to learn from this imaging technology! The prospect of understanding blinding eye diseases better is amazing.”
Prof. Tunde Peto.
In this 90min meeting, 6 users of Imagine Eyes’ adaptive optics (AO) technology shared their experience with cellular and microvascular retinal imaging in clinical settings.
They discussed recent clinical studies using rtx1 AO cameras, in a wide range of pathologies:
- retinitis pigmentosa and other inherited retinal diseases, including patients treated with gene therapy,
- age-related macular degeneration, from intermediate to geographic atrophy,
- arterial hypertension,
- neurodegenerative diseases.
The presentations included impressive images of retinal phenotypes at the microscopic scale, and quantitative assessment of cone cells, small vessel structure, and lesion edge progression. Some reported data from short term follow-up examinations, as well as practical tips on AO examination protocols and image interpretation for such patients.
The rtx1 provides high resolution imaging that is useful in observing early characteristics and short term changes in AMD, particularly hyporeflective clumps.
In patients treated with Luxturna at our clinic, there was no sign of inflammatory changes on adaptive optics images. And this is very important regarding further developments of genetic treatments.
Adaptive optics imaging offers new possiblities for the management of chronic diseases such as arterial hypertension. It offers quantitative biomarkers of the microcirculation, such as the WLR which may give insights into the average blood pressure over weeks.
In multiple sclerosis patients, the thickening of outer retina and loss of cones is quite a sensitive measure of inflammation, which is one of the early events in most neurodegenerative conditions, even Alzheimer and Down syndrome. So it probably has more specificity than looking at the later changes.
In this symposium, Imagine Eyes also introduced the new TFI module for rtx1 cameras. It enables novel explorations of the RPE layer at the microscopic scale, including in healthy retinas, of the mosaic of RPE cells. More information on the TFI module here.
We are very grateful to the chairpersons and speakers for sharing their insight during this event.
To know more about their experience and findings with AO retinal imaging, replay videos are available below (1 video per session).