rtx1 Adaptive Optics Retinal Camera

Track diseases at the microscopic scale in the retina

Imaging at the cellular level

When using the rtx1 Adaptive Optics Retinal Camera, you examine the retina at a scale where individual cells are visible. Its ultrahigh-resolution images reveal parafoveal cone photoreceptors as well as other microscopic retinal structures that cannot be seen with conventional techniques.

Imaging at the cellular level

Microvascular imaging

The rtx1 enables to visualize the microscopic walls of retinal arterioles non-invasively. Focal narrowing, perivascular sheathing, micro-hemorrhages and micro-aneurisms are also visible without using contrast agents.

Microvascular imaging

The rtx1 enables directly visualizing the microscopic walls of retinal arterioles. Focal narrowing, perivascular sheathing, micro-hemorrhages and micro-aneurisms are also visible without using contrast agents.

Two-second acquisition

fast adaptive optics imaging

Infrared illumination

comfortable for patients

Cellular-level follow-up

tracks very small changes

Over 100 publications

in a wide range of pathologies

Reference product

The rtx1 stands out as the most widely-used AO imaging device in medical centers throughout the world. Cleared by regulatory authorities in several countries, and proven by over 100 peer-reviewed publications, it has become the reference product for cellular-resolution retinal imaging.

See publications

Clinician-friendly

The time when AO technology could only be mastered by physicists and engineers belongs to the past. Designed in collaboration with clinicians, the rtx1 is driven by user-friendly software which enables high patient throughput. It is also comfortable for patients as image acquisition uses infrared illumination and only takes 2 seconds.

Clinician-friendly

Tracking microscopic progression/regression

By design, the rtx1 delivers images that are free from motion distortion. Building on this advantage, its software enables capturing the same retinal region through different visits, and automatically aligns follow-up images. This allows tracking minute changes in a group of cells, a vessel section, or a lesion over time.

Image credit: Quinze-Vingts National Eye Hospital, Paris, France

Geographic atrophy
Baseline
Geographic atrophy
+ 2 weeks
Geographic atrophy
+ 1 month
Geographic atrophy
+ 3 months
Geographic atrophy
+ 5 months

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Enable new advances in biomarkers

The rtx1 empowers clinical researchers to investigate an array of candidate biomarkers for assessing retinal anatomy and pathologies. Semi-automated software for analyzing the distribution of cell-like structures and the wall morphology of blood vessels is available, for research use only.

Enable new advances in biomarkers

Adaptive optics (AO) ophthalmoscopy is now an accessible tool to visualize photoreceptors in the human living retina. Several studies of human retinal photoreceptors in diabetic patients using Imagine Eyes’ AO retinal camera have been achieved.

Cristescu et al.Rom J Ophthalmol. 63(2): 153–160.

In all patients, AO images showed dark elements that were smaller than what could be resolved by fundus imaging and OCT

Bek. Acta Ophthalmologica 92, 753–758

The rtx1 demonstrates that, unlike the common belief, performing AO retinal imaging can be as easy as standard retinal imaging

Pr. Paques, Quinze-Vingt National Hospital July 2018, Paris, France

We, for the first time, visualized longitudinal changes during the recovery of cone photoreceptors in the eyes of VKH patients

Nakamura et al. Graefes Arch Clin Exp Ophthalmol (2018) 256:387

The image resolution achieved by this technology is superior to that of any other current diagnostic tool.

Zaleska-Zmijewska et al.Journal of Diabetes Research 2017, 1–9

Adaptive optics retinal imaging provided non-invasive and sensitive information on the pathologic disruption of the cone mosaic, even in the absence of subjective (visual loss) or objective (diagnostic imaging) abnormalities.

Ziccardi, L. et al. American Journal of Ophthalmology 160, 301–312.e6

Abnormal cone mosaic in an inherited retinal disease. Case of mild cone-rod distrophy in atypical Usher syndrome. The rtx1 images reveal disorganized and sparse cones cells, not only in the patient's eye but also in the relative's eye. The size of the displayed images is 200x200µm. From article of Kubota et al. published in Opthalmic Genetics, 2018.

Arteriolar remodeling during antihypertensive therapy. With the rtx1 micron-precision alignment of follow-up images , the change in the artery wall structure is easily confirmed. Initial iamges provided by Dr Rosembaum, Pitié-Salpétrière Hospital, Paris, France

Drusen in a patient with familial drusen. Even small drusen are easily visible due to changes in the cone mosaic. Courtesy K . Gocho, V. Sarda, S. Falah, J.A. Sahel M. Benchaboune, M. Ullern, and M. Paques, Quinze-Vingts National Eye Hospital, Paris, France

Edge of a geographic atrophy region in a retina suffering from dry AMD. The atrophic regions shows dark pigmented spots of various sizes over a bright background. Remaining cone mosaic is visible in the non artophic area. Courtesy K . Gocho, V. Sarda, S. Falah, J.A. Sahel M. Benchaboune, M. Ullern, and M. Paques, Quinze-Vingts National Eye Hospital, Paris, France

Microaneurism in a diabetic patient. This image was acquired while focusing the rtx1 at the photoreceptor layer. Although the aneurism is slightly out of focus, it is highly visible. Diabetic retinopathy could not be detected by other techniques in this patient. See also the next image gallery. Courtesy Dr Marco Lombardo, Bietti Fundation, Roma, Italy

Microaneurism in a diabetic patient. This image was acquired with the rtx1 while focusing at retinal vessels. The aneurism is in focus and can be recognized by the bright central reflex due to its dome shape. Diabetic retinopathy could not be detected by other techniques in this patient. See also the next image. Courtesy : Dr Marco Lombardo, Bietti Fundation, Roma, Italy

OD_20140820113524_X2.0N_Y0.0_Z200.0 microaneurism-r100

Hard exudate. THe image was acquired while focussing on the retinal blood vessels. Courtesy Dr Kiyoko Gocho, Nippon Medical School Hokusoh Hospital, Chiba, Japan.

Lamina cribrosa in a healthy subject's eye.

Lamina cribrosa in a healthy cynomolgus monkey.

AOimage 3.3 acquisition mode, vessels, follow up

Links & Downloads

Product brochure
rtx1-e AO retinal camera

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Specifications

Imaging type	En face reflectance imaging
Detection type	Low-noise CCD camera
Illumination	Near infrared LED, 850nm
Exposure time	< 10 ms

Imaging field of view ¹	4° x 4°
Fixation stimulation range	H ± 14.5° / V ± 10°
Camera pixel pitch on the fundus ¹	1.1 µm
Optical resolution on the fundus ^{1, 2}	250 line pairs per millimeter (lppmm)

Adaptive optics control	Fully automated, resistant to blinking and movement
Depth focussing range ¹	1600 µm

Pupil diameter	≥ 4 mm
Refractive error compensation	-12 to +6 D

Total footprint (WxDxH)	137x53x132-162 cm

¹ Some specifications are dependent on several factors including but not limited to: ocular biometry, pupil diameter, optical defects, ocular media transparency.
² The system can image line pairs of 2 µm in line width.

The rtx1 is an approved medical device in the European Union (device class 2a) and in Japan. In the USA, the rtx1 has not received FDA clearance. It is an investigational device and requires Institutional Review Board (IRB) oversight for use in any research application. Further information is provided in the user documentation.

rtx1 Adaptive Optics Retinal Camera

Track diseases at the microscopic scale in the retina

Imaging at the cellular level

Imaging at the cellular level

Microvascular imaging

Microvascular imaging

Two-second acquisition

Infrared illumination

Cellular-level follow-up

Over 100 publications

Reference product

Clinician-friendly

Clinician-friendly

Tracking microscopic progression/regression

Geographic atrophy

Geographic atrophy

Geographic atrophy

Geographic atrophy

Geographic atrophy

Enable new advances in biomarkers

Enable new advances in biomarkers

Links & Downloads

Published articles

Biomarker software

Auto-Montage Software

Specifications

Contact us for more information

Imagine Eyes

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rtx1 Adaptive Optics Retinal Camera

Track diseases at the microscopic scale in the retina

Imaging at the cellular level

Imaging at the cellular level

Microvascular imaging

Microvascular imaging

Reference product

Clinician-friendly

Clinician-friendly

Tracking microscopic progression/regression

Geographic atrophy

Geographic atrophy

Geographic atrophy

Geographic atrophy

Geographic atrophy

Enable new advances in biomarkers

Enable new advances in biomarkers

Links & Downloads

Specifications

Contact us for more information

Imagine Eyes

Need help?

Community

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