rtx1 Adaptive Optics Retinal Camera
Regulatory approved medical device in several countries
When using the rtx1 Adaptive Optics Retinal Camera, you examine the retina at a scale where individual cells are visible. It reveals parafoveal cone photoreceptors as well as other microscopic retinal structures that cannot be seen with conventional techniques, thanks to a 10 times better resolution.
The rtx1 enables visualizing the microscopic walls of retinal arterioles non-invasively. Focal narrowing, perivascular sheathing, micro-hemorrhages and micro-aneurisms are also visible without using contrast agents.
The TFI add-on module extends the imaging capability of rtx1 for investigating retinal anatomy, pathology and therapy. Using transscleral illumination, rtx1-TFI enables visualizations of otherwise invisible microscopic detail in the retinal pigment epithelium, as well as pigment redistribution in retinal degeneration.
Most existing rtx1 units can be upgraded with the TFI module.
No compromise on patient comfort
Designed for multicenter trials
Micrometric progressions revealed
Fast annotations and analyzes
Automated montage with DualAlign®
Extensively validated technology
The rtx1 stands out as the most widely-used AO imaging device throughout the world. Cleared by regulatory authorities in several countries, and adopted by 90 clinical centers, it has become the reference device for cellular-level retinal assessments in clinical research. More than 250 publications illustrate the extensive clinical knowledge and findings that users of the rtx1 AO camera have gained in a large variety of diseases that impact the retina.
Designed in collaboration with clinicians, the rtx1 enables comfortable and quick examination for high patient throughput.
The Protocols functionality guides users through every step of virtually any imaging procedure. It enables accelerating and standardizing AO examinations in multicenter studies.
By design, the rtx1 delivers images that are free from motion distortion. Building on this advantage, the software makes it easy to capture multiple regions of interest through different visits, and automatically registers follow-up images. This allows tracking minute changes in groups of cells, vessels, or lesions over time.
With AOdetect application, rtx1 delivers an array of candidate biomarkers for assessing the distribution of parafoveal cone cells, as well as RPE cells on TFI images :
On follow-up images, AOdetect enables analyzing the exact same region of interest, for monitoring a given group of cells over time.
AOdetect application also provides supervised image segmentation for analyzing the wall morphology of blood vessels. With this option, rtx1 delivers non-invasive vascular structure metrics with micrometer precision:
The exact same vascular section is assessed on follow-up images with a only a few clicks.
Flicker stimulation with rtx1 enables micron-precision assessments of neurovascular response in health conditions and diseases that affect small blood vessels.
The rtx1 software provides protocols for investigating alterations in the directional reflectance of retinal microscopic structures.
Gaze-dependent imaging enables visualizations of small drusen with enhanced contrast (figure: Rossi et al., TVST 2021).
Incidence-dependent imaging allows exploring pathological changes in photoreceptor reflectance, in relation with the stiles-cawford effect.
Imaging type | En face reflectance imaging |
Detection type | Low-noise CCD camera |
Illumination | Near infrared LED, 850nm |
Exposure time | < 10 ms |
Imaging field of view 1 | 4° x 4° |
Fixation stimulation range | H ± 14.5° / V ± 10° |
Camera pixel pitch on the fundus 1 | 1.1 µm |
Optical resolution on the fundus 1, 2 | 250 line pairs per millimeter (lppmm) |
Adaptive optics control | Fully automated, resistant to blinking and movement |
Depth focussing range 1 | 1600 µm |
Pupil diameter | ≥ 4 mm |
Refractive error compensation | -12 to +6 D |
Total footprint (WxDxH) | 137x53x132-162 cm |
1 Some specifications are dependent on several factors including but not limited to: ocular biometry, pupil diameter, optical defects, ocular media transparency.
2 The system can image line pairs of 2 µm in line width.
rtx1 is a certified medical device of class IIa in the European Union. rtx1 is an approved medical device in Japan, China and Korea. In the USA, rtx1 has not received FDA clearance; it is an investigational device that requires Institutional Review Board (IRB) oversight.
rtx1 with AOdetect is certified in the European Union, Japan and Korea. rtx1 with TFI is certified in the European Union.
In other territories, rtx1 with AOdetect or TFI are for research use only.
For use by trained eyecare professionals only.
All retinal images on this page are courtesy of: Quinze-Vingts National Eye Hospital, Paris, France.
i2k is not part of the rtx1 product. i2k has not been approved for clinical use. It is for research use only. DualAlign, i2k, i2k Retina AO are trademarks of DualAlign LLC.