In a clinical case series study published in Ophthalmic Surgery, Lasers and Imaging Retina, a team of ophthalmologists led by Prof Shuhei Kameya at the Nippon Medical School (Chiba, Japan) has used the rtx1 Adaptive Optics Retinal Camera to assess cone photoreceptor cells in female carriers of choroideremia.
All these carriers had normal visual acuity and electroretinograms, however retinal abnormalities were observed in most of them using conventional fundoscopy. On the opposite, rtx1 images of cone photoreceptors revealed regular cell mosaics. Adaptive optics findings were thus found to be more consistent with visual performance findings
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Article reference: Suzuki, K. et al. High-Resolution Retinal Imaging Reveals Preserved Cone Photoreceptor Density and Choroidal Thickness in Female Carriers of Choroideremia. Ophthalmic Surgery, Lasers and Imaging Retina 50, 76–85 (2019).