Visual cell loss revealed in asymptomatic RPGR mutation carriers

An adaptive optics study conducted at the Lions Eye Institute was recently published in Investigative Ophthalmology & Vision Sciences.

It reports severe photoreceptor loss in asymptomatic RPGR mutation carriers, revealed by rtx1 AO camera.



“Cone density (CD) and pointwise sensitivity (PWS) may help characterize early structural and functional defects in asymptomatic carriers who manifest normal visual acuity and unremarkable SD-OCT. The more prominent CD defect compared with PWS defect in asymptomatic patients suggests that AO imaging may be more useful in early detection of structural damage in these patients.”



Article reference: Roshandel, D., Lamey, T. M., Charng, J., Heath Jeffrey, R., McLaren, T., et al. (2023). Microperimetry and Adaptive Optics Imaging Reveal Localized Functional and Structural Changes in Asymptomatic RPGR Mutation Carriers. Investigative Ophthalmology & Visual Science January 2023, Vol.64, 3.