Press release May 4, 2007

Leading researchers explore the applications of adaptive optics for improving the outcome of refractive surgery and commercial lens development.

Leading researchers explore the applications of adaptive optics for improving the outcome of refractive surgery and commercial lens development

World renowned surgeons and researchers use Imagine Eyes’™ adaptive optics products with the aim of improving

the success rate of refractive surgery procedures as well as facilitating the design of new intraocular (IOL) and

custom-wavefront lenses.

Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), FT. LAUDERDALE, FL – May

6, 2007 – During the 2007 annual meeting of ARVO, Imagine Eyes’ customers will prove the company’s leadership in

developing adaptive optics products for ophthalmology. Researchers from world renowned clinics and universities will

present results from studies conducted using the company’s products, including the crx1™ Adaptive Optics Visual

Simulator and mirao™ 52-d Electromagnetic Deformable Mirror, to simulate the influence on vision of high-order

aberrations that play a pivotal role in choosing between various refractive treatment options to ensure optimal results.

In independent studies, two separate research teams used the crx1 to induce and correct for higher-order (coma,

trefoil and spherical) aberrations, in addition to correcting for regular optical defects (defocus and astigmatism). Dr.

Karoline Maia Rocha1, in collaboration with Dr. Ronald Krueger’s2 team, performed a study showing that simulating

the correction of higher-order aberrations in varying degrees can help clinicians improve overall visual acuity and

patient comfort when choosing between different refractive surgery techniques. Dr. Jean Luc Nhuyen Koa3, used the

same device to perform postoperative evaluations of patients presenting above average preoperative normal and

higher-order aberrations. In both cases, amelioration is based on the best visual acuity that subjects could achieve

with the best possible spectacle correction versus that of simulated refractive surgery.

In parallel, Dr. Guenyoung Yoon4 will present the results from his work using Imagine Eyes’ products as part of an

adaptive optics system he and his team designed and built to investigate mirao’s ability to correct for the large

amounts of aberrations found in highly-aberrated eyes, including those of keratoconic subjects presenting extreme

higher-order aberrations. Dr. Yoon summarized his work by saying “Aberrations in both normal and highly aberrated

eyes were successfully corrected using the large-stroke mirao 52-d deformable mirror.” Adding that “This mirror can

be a powerful tool to assess the limit of visual performance achievable after correcting for subjects’ aberrations,

especially in eyes with abnormal corneal profiles.” Funding for Dr. Yoon’s work was provided through NIH/NEI grant

R01EY014999, NYSTAR/CEIS, Research to Prevent Blindness.

Currently, surgeons rely on wavefront aberrometer measurements to qualify patients for custom wavefront guided or

standard laser surgery, but presbyobic patients often require specialized analysis. The crx1 can enable doctors to

simulate the effect of various refractive techniques, in a totally non-invasive and reversible manner, in order to choose

the optical or surgical correction that will provide the best combination of visual acuity and patient comfort. These

remarkable research projects provide new diagnostic avenues for practitioners, offering new hope to patients and

reducing the necessity for secondary postoperative corrective procedures.

Industrials will be able to use this research to develop new clinical techniques, including aspheric and asymmetrical

IOL designs that may improve the far-field vision of patients affected by presbyopia, a disorder that affects nearly

everyone over the age of 45. In the near future, this research may equally benefit patients that suffer from

keratoconus by allowing doctors to simulate and pre-test the visual effects of different rigid and custom-wavefront soft

contact lens designs.

Additionally during ARVO, Pr. Wolfgang Drexler5 will receive the prestigious Cogan Award for his work using Imagine

Eyes’ adaptive optics products to produce ultra high-resolution images of the living human retina and the prospects his

accomplishment offers to patients suffering from retinal diseases.

Imagine Eyes will be resent at ARVO stand 912. For more information, please visit our website at www.imagineeyes.

com or contact our Director of Communications, Mark Zacharria at This e-mail address is being protected from spam bots, you need JavaScript enabled to view it or +33

(0)6.81.55.99.06 (reachable at ARVO).

1) Federal University of São Paulo, São Paulo, Brazil. 2) Cole Eye Institute, Cleveland Clinic, Cleveland, OH USA. 3) Clinique de la Vision, Paris

France. 4) Ophthalmology/Institute of Optics/Center for Visual Science, University of Rochester. 5) Biomedical Imaging Group, Department of

Optometry and Vision Sciences, Cardiff University, Wales, UK

About Imagine Eyes

Imagine Eyes is an ophthalmic medical device company that applies its unique expertise in ocular wavefront

metrology and adaptive optics to focus on professional’s needs for ophthalmic diagnostic devices that cannot

effectively be addressed by other means. The company, founded in 2003 by leading scientists in the fields of adaptive

optics and eye research, maintains its position as a technical leader in this domain through its innovative research and

development program, wide array of patents and acclaimed product line.

©2007 Imagine Eyes. All rights reserved. Imagine Eyes, the Imagine Eyes logo, irx3, crx1, and mirao are trademarks and/or registered trademarks

of Imagine Eyes. Maxwell is a registered trademark of Ziemer Ophthalmic Systems. Communications managed by Elucido Partners www.elucidopartners.

net.

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